PAI1 Polyclonal Antibody

• Background :

  Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU) . As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading.Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis.

• Abbreviation :

  PAI1

• UniProt :

  P20961

• Host :

  Rabbit

• Reactivity :

  Rat

• Immunogen :

  Recombinant Rat PAI1 protein expressed by Mammalian

• Target :

  Plasminogen activator inhibitor 1; PAI-1; Endothelial plasminogen activator inhibitor; Serpin E1; SERPINE1; PLANH1

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB

• Field of Research :

  Cancer; Cell Biology; Metabolism

• Purification :

  Antigen Affinity Purification

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:250-1:500

• Buffer :

  PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  45 kDa

• Observed Molecular Weight :

  47 kDa

• Isotype :

  IgG