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Chromogranin A Polyclonal Antibody

CAT: 0763-E-AB-40339-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-40339-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Chromogranin A is a member of the granin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells. Chromogranin A is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine) . CgA is one of the most used tumor markers in NET's (neuroendocrine tumors), and elevated CgA concentrations have been demonstrated in serum or plasma of patients with different types of these tumors.
Abbreviation
Chromogranin A
UniProt
P26339
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant Mouse Chromogranin-A protein
Target
Beta Granin; betagranin (N-terminal fragment of chromogranin A) ; catestatin; CgA; CHG A; Chga; chromofungin; Chromogranin A; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; CMGA; ER-37; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; Secretory protein I; SP I; SP-I; SP1; SPI; Vasostatin; Vasostatin I; Vasostatin II
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Neuroscience; Signal Transduction; Tags and Cell Markers
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:100-1:300
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
51 kDa
Observed Molecular Weight
51 kDa
Isotype
IgG

UniProtKB · P26339

Chromogranin-A

CMGA_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P26339
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Chga
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
CgA
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Technical term

3D-structureReference proteome

PTM

AmidationCleavage on pair of basic residuesDisulfide bondGlycoproteinOxidationPhosphoproteinProteoglycanPyrrolidone carboxylic acid

Ligand

Calcium

Cellular component

Cytoplasmic vesicleSecreted

Domain

Signal
Product Datasheet
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