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FAS Polyclonal Antibody

CAT: 0763-E-AB-40063-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-40063-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC) . FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.
Abbreviation
FAS
UniProt
P25445
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant Human Tumor necrosis factor receptor superfamily member 6 protein
Target
ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; Fas (TNF receptor superfamily; member 6) ; FAS 1; FAS 827dupA; Fas AMA; Fas; FAS Antigen; Fas cell surface death receptor; FAS1; FASLG receptor; FASTM; sFAS; Surface antigen APO1; TNF receptor superfamily; member 6; TNFRSF 6; TNFRSF6; TNR6; Tumor necrosis factor receptor superfamily member 6
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Cell Biology; Immunology
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:50-1:100
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
37kDa
Observed Molecular Weight
45kDa
Citation 01
https://www.frontiersin.org/articles/10.3389/fonc.2021.735183/full
Citation 02
https://www.mdpi.com/1422-0067/20/3/757
Citation 03
https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.22942
Citation 04
https://www.sciencedirect.com/science/article/pii/S0006291X19316687
Isotype
IgG
Product Datasheet
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