SMAD2 Polyclonal Antibody

• Background :

  Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.

• Abbreviation :

  Smad2

• UniProt :

  Q15796

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human Smad2 around the non-phosphorylation site of Ser250.

• Target :

  Drosophila; homolog of; MADR2; hMAD-2; HsMAD2; JV18; JV18-1; JV181; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mother against DPP homolog 2; Mothers against decapentaplegic homolog 2; Mothers against decapentaplegic; Drosophila; homolog of;2; Mothers against DPP homolog 2; OTTHUMP00000163489; Sma and Mad related protein 2; Sma- and Mad-related protein 2 MAD; SMAD 2; SMAD family member 2; SMAD; mothers against DPP homolog 2; SMAD2; SMAD2

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC-p

• Field of Research :

  Cancer; Epigenetics and Nuclear Signaling; Signal Transduction; Stem Cells

• Purification :

  Affinity purification

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:100-1:300

• Buffer :

  PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  52kDa

• Observed Molecular Weight :

  52kDa

• Isotype :

  IgG