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E-Cadherin Polyclonal Antibody

CAT: 0763-E-AB-31261-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-31261-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
Abbreviation
E-cadherin
UniProt
P12830
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from the N-terminal region of human E-cadherin
Target
Arc 1; CADH1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 324; CD324; CD324 antigen; cdh1; CDHE; E-Cad/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC-p; IF
Field of Research
Cancer; Developmental Biology; Signal Transduction
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
97kDa
Observed Molecular Weight
100kDa
Citation 01
https://europepmc.org/article/pmc/pmc8712759?javascript_support=no
Citation 02
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068511/
Citation 03
https://www.nature.com/articles/srep33856
Citation 04
https://www.hindawi.com/journals/cjgh/2022/5332129/
Citation 05
https://www.spandidos-publications.com/10.3892/ol.2018.9251?text=abstract
Citation 06
https://www.spandidos-publications.com/10.3892/mmr.2021.12471
Citation 07
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8607078/
Isotype
IgG

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