Pan-Akt Polyclonal Antibody

Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity) . General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI (3) K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) . Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.

Akt

P31749, P31751, Q9Y243

Human; Mouse; Rat

Synthesized peptide derived from human Akt around the non-phosphorylation site of Tyr315.

AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha; AKT2; RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B

Unconjugated

WB; IHC-p; IF

Cancer; Neuroscience; Signal Transduction

Affinity purification

1mg/mL

WB 1:500-1:2000; IHC 1:100-1:300; IF 1:50-1:200

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

56kDa

50kDa

https://www.sciencedirect.com/science/article/pii/S0304383521004031

https://www.sciencedirect.com/science/article/pii/S1874939923000160

https://link.springer.com/article/10.1007/s11060-022-03992-y

https://www.spandidos-publications.com/10.3892/ijmm.2021.4884

https://www.sciencedirect.com/science/article/pii/S0024320520316994

https://link.springer.com/article/10.1007/s10142-023-00965-w

https://link.springer.com/article/10.1007/s12032-022-01649-4

https://link.springer.com/article/10.1007/s12192-020-01142-9