AKT1 Polyclonal Antibody

Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity) . General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI (3) K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) . Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.

Akt1

P31749

Human; Mouse; Rat

Synthesized peptide derived from human Akt1 around the non-phosphorylation site of Thr450.

AKT 1; AKT; AKT1; AKT1; MGC99656; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha

Unconjugated

WB; IHC-p

Cancer; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction

Affinity purification

1 mg/mL

WB 1:500-1:2000; IHC 1:100-1:300

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

56kDa

55kDa

https://www.sciencedirect.com/science/article/pii/S0753332219332202

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351449/