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STL127705

CAT: 0804-HY-122727-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122727-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis[1][2].
CAS Number
1326852-06-5
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; DNA-PK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stl127705.html
Purity
98.97
Solubility
DMSO : < 1 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C1NC2=NC(NCCC3=CC=C(OC)C(OC)=C3)=NC=C2C(N1C4=CC=CC(F)=C4)=O
Molecular Formula
C22H20FN5O4
Molecular Weight
437.42
Precautions
H315, H319, H320
References & Citations
[1]Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst) . 2016 Jul;43:98-106.|[2]Guo N, et al. Inhibiting nonhomologous end-joining repair would promote the antitumor activity of gemcitabine in nonsmall cell lung cancer cell lines. Anticancer Drugs. 2022 Jun 1;33 (5) :502-508.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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