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GRIK3 Polyclonal Antibody

CAT: 0763-E-AB-19967-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-19967-01Size:20 µL
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Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2) . A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.
Abbreviation
GRIK3
UniProt
Q13003
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human GRIK3
Target
EAA5; Excitatory amino acid receptor 5; GLR 7; GLR7; GLU R7; GLUR 7; GluR 7a; GluR-7; GluR7; GluR7a; Glutamate receptor 7; Glutamate receptor; Glutamate receptor ionotropic kainate 3; GRIK 3; GRIK3; GRIK3; ionotropic kainate 3
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Neuroscience
Purification
Antigen affinity purification
Concentration
1.5 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
104 kDa
Observed Molecular Weight
Refer to figures
Isotype
IgG

UniProtKB · Q13003

Glutamate receptor ionotropic, kainate 3

GRIK3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13003
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GRIK3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GluK3
EC number
—
Processing
Precursor
Secondary accessions
A9Z1Z8, B1AMS6, Q13004, Q16136
Protein keywords

Coding sequence diversity

Alternative splicingRNA editing

Cellular component

Cell membraneMembranePostsynaptic cell membraneSynapse

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

Ion channelLigand-gated ion channelReceptor

Biological process

Ion transportTransport

Technical term

Proteomics identificationReference proteome

Domain

SignalTransmembraneTransmembrane helix

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