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Bisandrographolide A

CAT: 0804-HY-N2940-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2940-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound[1][2].
CAS Number
160498-00-0
Product Name Alternative
BAA
UNSPSC
12352005
Target
TRP Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bisandrographolide-a.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C(C2C=C(/C=C/[C@H]3[C@@](CC[C@@H](O)[C@@]4(C)CO)(C)[C@]4([H])CCC3=C)C(O2)=O)C[C@H]5[C@@](CC[C@@H](O)[C@@]6(C)CO)(C)[C@]6([H])CCC5=C)=CCO1
Molecular Formula
C40H56O8
Molecular Weight
664.87
References & Citations
[1]Yue GG, et al. Identification of active components in Andrographis paniculata targeting on CD81 in esophageal cancer in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154183.|[2]Vriens J, et al. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem. 2007 Apr 27;282 (17) :12796-803.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
TRPV4

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T13582-01Bisandrographolide C

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