RNF111 Polyclonal Antibody

• Background :

  The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

• Abbreviation :

  RNF111

• UniProt :

  Q6ZNA4

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Fusion protein of human RNF111

• Target :

  ARK; Arkadia; DKFZp313E0731; DKFZp686H1966; DKFZp761D081; E3 ubiquitin protein ligase Arkadia; E3 ubiquitin-protein ligase Arkadia; FLJ38008; RING finger protein 111; RN111; RNF 111; RNF111

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC

• Field of Research :

  Cell Biology; Signal transduction

• Purification :

  Antigen affinity purification

• Concentration :

  0.84 mg/mL

• Dilution :

  IHC 1:50-1:300

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype :

  IgG