LRP6 Polyclonal Antibody

• Background :

  This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

• Abbreviation :

  LRP6

• UniProt :

  O75581

• Host :

  Rabbit

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthetic peptide of human LRP6

• Target :

  ADCAD2; C030016K15Rik; Cd; FLJ90062; FLJ90421; LDL receptor related protein 6; Low density lipoprotein receptor related protein 6; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6; LRP6; OTTHUMP00000238979; OTTHUMP00000238980; OTTHUMP00000238982; STHAG7

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC

• Field of Research :

  Cancer; Signal transduction; Stem cells

• Purification :

  Affinity purification

• Concentration :

  1.4 mg/mL

• Dilution :

  IHC 1:40-200

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Citation 01 :

  https://www.frontiersin.org/articles/10.3389/fonc.2018.00470/full

• Isotype :

  IgG