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PKC gamma Polyclonal Antibody

CAT: 0763-E-AB-16194-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-16194-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14) .
Abbreviation
PRKCG
UniProt
P05129
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human PRKCG
Target
KPCG; MGC57564; OTTHUMP00000067291; PKC-gamma; PKCC; PKCG; PRKCG; Protein kinase C gamma; Protein kinase C gamma polypeptide; Protein kinase C gamma type; Protein kinase C; gamma; SCA 14; SCA14
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Neuroscience; Signal Transduction
Purification
Affinity purification
Concentration
0.7 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
78kDa
Isotype
IgG

UniProtKB · P05129

Protein kinase C gamma type

KPCG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05129
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRKCG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PKC-gamma
EC number
2.7.11.13
Processing
—
Secondary accessions
B7Z8Q0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingCalciumMetal-bindingNucleotide-bindingZinc

Biological process

Biological rhythms

Cellular component

Cell membraneCell projectionCytoplasmMembraneSynapseSynaptosome

Disease

Disease variantNeurodegenerationSpinocerebellar ataxia

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinUbl conjugation

Domain

RepeatZinc-finger

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