KCNJ11 Polyclonal Antibody

CAT: 0763-E-AB-14986-01Size: 20 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-14986-01Size:20 µL

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Background

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM) . Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Abbreviation

KCNJ11

UniProt

Q14654

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human KCNJ11

Target

ATP sensitive inward rectifier potassium channel 11; Beta cell inward rectifier subunit; BIR; HHF 2; HHF2; IKATP; Inward rectifier K (+) channel Kir6.2; Inwardly rectifying potassium channel KIR6.2; IRK 11; IRK11; KCNJ11; Kir 6.2; Kir6.2; MGC133230; PHHI; Potassium channel inwardly rectifing subfamily J member 11; Potassium channel; inwardly rectifying subfamily J member 11; Potassium inwardly rectifying channel J11; TNDM 3; TNDM3

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Cardiovascular; Metabolism; Neuroscience; Signal Transduction

Purification

Affinity purification

Concentration

0.7 mg/mL

Dilution

IHC 1:50-1:200

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG

UniProtKB · Q14654

ATP-sensitive inward rectifier potassium channel 11

KCJ11_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q14654
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: KCNJ11
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B4DWI4, E9PNK0, Q2M1H7, Q58EX3, Q8IW96

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMetal-bindingNucleotide-bindingPotassium

Disease

Diabetes mellitusDisease variant

PTM

Disulfide bondPhosphoprotein

Molecular function

Ion channelVoltage-gated channel

Biological process

Ion transportPotassium transportTransport

Cellular component

Membrane

Domain

TransmembraneTransmembrane helix

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