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Recombinant Human Perforin-1 (PRF1)

CAT: 0013-GTR19021219-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR19021219-01Size:20 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Plays a key role in secretory granule-dependent cell death, and in defence against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Tag
N-terminal MBP-tagged and C-terminal 6xHis-tagged
Purity
Greater than 85% as determined by SDS-PAGE
Molecular Weight
103.2 kDa
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 ̊C, -80 ̊C. The shelf life of lyophilized form is 12 months at -20 ̊C, -80 ̊C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 ̊C for up to one week.
Notes
For research use only.
Preservative
Tris-based buffer, 50% glycerol
AA Sequence
Full Length of Mature Protein

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