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MMP14 Polyclonal Antibody

CAT: 0763-E-AB-14218-03Size: 120 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-14218-03Size:120 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Abbreviation
MMP14
UniProt
P50281
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human MMP14
Target
Matrix metallopeptidase 14 (membrane inserted) ; Matrix metalloproteinase 14; Matrix metalloproteinase-14; Membrane type 1 matrix metalloproteinase; Membrane type 1 metalloprotease; Membrane type matrix metalloproteinase 1; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP 14; MMP X1; MMP-14; MMP-X1; Mmp14; MMP14; MMPX1; MT MMP 1; MT-MMP 1; MT1 MMP; MT1-MMP; MT1MMP; MTMMP 1; MTMMP1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Cell Biology; Cardiovascular; Metabolism; Signal Transduction
Purification
Affinity purification
Concentration
0.4 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P50281

Matrix metalloproteinase-14

MMP14_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P50281
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MMP14
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MMP-14
EC number
3.4.24.80
Processing
Precursor
Secondary accessions
A8K5L0, Q6GSF3, Q92678
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-bindingZinc

Cellular component

Cell membraneCytoplasmMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondPhosphoproteinZymogen

Disease

Disease variantOsteoporosis

Molecular function

HydrolaseMetalloproteaseProtease

Domain

RepeatSignalTransmembraneTransmembrane helix

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