STAT4 Polyclonal Antibody

CAT: 0763-E-AB-13826-02Size: 60 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-13826-02Size:60 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.

Abbreviation

STAT4

UniProt

Q14765

Host

Rabbit

Reactivity

Human; Mouse

Immunogen

Recombinant protein of human STAT4

Target

Signal transducer and activator of transcription 4; SLEB11; STAT4; STAT4

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Epigenetics and Nuclear Signaling; Signal Transduction

Purification

Affinity purification

Concentration

1.2 mg/mL

Dilution

IHC 1:50-1:200

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG

UniProtKB · Q14765

Signal transducer and activator of transcription 4

STAT4_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q14765
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: STAT4
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q96NZ6

Protein keywords

PTM

AcetylationPhosphoprotein

Molecular function

ActivatorDNA-binding

Cellular component

CytoplasmNucleus

Disease

Disease variantSystemic lupus erythematosus

Technical term

Proteomics identificationReference proteome

Domain

SH2 domain

Biological process

TranscriptionTranscription regulation

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Alternative Products

Catalog	Name
JOT-AP14542-01	Stat4 Polyclonal Antibody
BS78368	STAT4 polyclonal antibody