CASP3 Polyclonal Antibody

• Background:

  This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

• Abbreviation:

  CASP3

• UniProt:

  P42574

• Host:

  Rabbit

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Recombinant protein of human CASP3

• Target:

  A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Cancer; Cell Biology; Metabolism; Neuroscience

• Purification:

  Affinity purification

• Concentration:

  0.5 mg/mL

• Dilution:

  WB 1:200-1:1000; IHC 1:50-1:200

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  32kDa

• Citation 01:

  https://www.sciencedirect.com/science/article/pii/S1382668922001739

• Citation 02:

  https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-022-00747-3

• Citation 03:

  https://europepmc.org/article/pmc/pmc8333701?javascript_support=no

• Citation 04:

  https://www.sciencedirect.com/science/article/pii/S0300483X18303937

• Citation 05:

  https://link.springer.com/article/10.1007/s12011-018-1535-3

• Citation 06:

  https://www.sciencedirect.com/science/article/pii/S2666027X22000093

• Isotype:

  IgG