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CASP3 Polyclonal Antibody

CAT: 0763-E-AB-13815-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-13815-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Abbreviation
CASP3
UniProt
P42574
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human CASP3
Target
A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Cell Biology; Metabolism; Neuroscience
Purification
Affinity purification
Concentration
0.5 mg/mL
Dilution
WB 1:200-1:1000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
32kDa
Citation 01
https://www.sciencedirect.com/science/article/pii/S1382668922001739
Citation 02
https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-022-00747-3
Citation 03
https://europepmc.org/article/pmc/pmc8333701?javascript_support=no
Citation 04
https://www.sciencedirect.com/science/article/pii/S0300483X18303937
Citation 05
https://link.springer.com/article/10.1007/s12011-018-1535-3
Citation 06
https://www.sciencedirect.com/science/article/pii/S2666027X22000093
Isotype
IgG

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