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BAX Polyclonal Antibody

CAT: 0763-E-AB-13814-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-13814-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Abbreviation
BAX
UniProt
Q07812
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human BAX
Target
Apoptosis regulator BAX; BAX; Bax-protein; BAX; BAXA; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2 associated X protein omega; BCL2 associated X protein transcript variant delta2; Bcl2-L-4; BCL2L4; membrane isoform alpha
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Cell Biology; Metabolism
Purification
Affinity purification
Concentration
0.2 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:25-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
21kDa
Citation 01
https://www.mdpi.com/1806946
Citation 02
https://www.sciencedirect.com/science/article/pii/S0753332220302663
Citation 03
https://www.sciencedirect.com/science/article/pii/S0024320522002600
Citation 04
https://link.springer.com/content/pdf/10.1007/s13311-019-00803-7.pdf
Citation 05
https://link.springer.com/article/10.1186/s12902-022-01143-y
Citation 06
https://www.sciencedirect.com/science/article/pii/S0300483X18303937
Citation 07
https://link.springer.com/article/10.1007/s10895-023-03180-9
Citation 08
https://www.sciencedirect.com/science/article/pii/S0006291X19321874
Citation 09
https://link.springer.com/article/10.1007/s10123-018-00051-3
Citation 10
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106821/
Isotype
IgG

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