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HTRA3 Polyclonal Antibody

CAT: 0763-E-AB-13006-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-13006-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HtrA3, also known as PRSP (pregnancy-related serine protease), is a 453 amino acid secreted protein that contains one PDZ domain, one Kazal-like domain and one IGFBP N-terminal domain. Widely expressed with particularly high expression in ovary, heart, placenta and bladder, HtrA3 functions as a probable serine protease that is thought to play an important role in placental development. HtrA3 is downregulated in ovarian tumors, suggesting an alternative role in tumor suppression. HtrA3 exists as two alternatively spliced isoforms, designated short and long. The gene encoding HtrA3 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
Abbreviation
HTRA3
UniProt
P83110
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human HTRA3
Target
High temperature requirement factor A3; High-temperature requirement factor A3; HtrA serine peptidase 3; HTRA3; HTRA3; Pregnancy related serine protease; Pregnancy-related serine protease; Probable serine protease HTRA3; PRSP; Serine protease HTRA3; Tasp
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Signal Transduction
Purification
Affinity purification
Concentration
0.2 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P83110

Serine protease HTRA3

HTRA3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P83110
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HTRA3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.-
Processing
Precursor
Secondary accessions
Q7Z7A2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Disulfide bond

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

Domain

Signal

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