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ALDH5A1 Polyclonal Antibody

CAT: 0763-E-AB-12961-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-12961-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD (+) -dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA) . In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene.
Abbreviation
ALDH5A1
UniProt
P51649
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human ALDH5A1
Target
Aldedehyde dehydrogenase 5 family; Aldehyde dehydrogenase 5 family member A1; Aldehyde dehydrogenase 5A1; Aldehyde dehydrogenase family 5 member A1; ALDH5A 1; Aldh5a1; mitochondrial; Mitochondrial succinate semialdehyde dehydrogenase; NAD (+) dependent succinic semialdehyde dehydrogenase; NAD (+) -dependent succinic semialdehyde dehydrogenase; SSADH; SSDH; SSDH; Succinate semialdehyde dehydrogenase; Succinate-semialdehyde dehydrogenase
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Metabolism; Neuroscience; Signal Transduction
Purification
Affinity purification
Concentration
0.5 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P51649

Succinate-semialdehyde dehydrogenase, mitochondrial

SSDH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P51649
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ALDH5A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.2.1.24
Processing
Precursor
Secondary accessions
B2RD26, G5E949, Q546H9, Q8N3W6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationDisulfide bondPhosphoprotein

Coding sequence diversity

Alternative splicing

Disease

Disease variant

Cellular component

Mitochondrion

Ligand

NAD

Molecular function

Oxidoreductase

Domain

Transit peptide

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