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MAP2K2 Polyclonal Antibody

CAT: 0763-E-AB-12553-03Size: 120 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-12553-03Size:120 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Abbreviation
MAP2K2
UniProt
P36507
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human MAP2K2
Target
Cardiofaciocutaneous syndrome; CFC syndrome; CFC4; Dual specificity mitogen activated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; FLJ26075; MAP kinase kinase 2; map2k2; MAPK / ERK kinase 2; MAPK/ERK kinase 2; MAPKK 2; MAPKK2; MEK 2; MEK2; Microtubule associated protein kinase kinase 2; Mitogen activated protein kinase kinase 2; Mitogen activated protein kinase kinase 2 p45; MKK 2; MKK2; MP2K2; OTTHUMP00000165826; OTTHUMP00000165827; PRKMK 2; PRKMK2
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Signal Transduction
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
WB 1:1000-1:5000; IHC 1:100-1:300
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
44kDa
Isotype
IgG

UniProtKB · P36507

Dual specificity mitogen-activated protein kinase kinase 2

MP2K2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P36507
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP2K2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase kinase 2, MAPKK 2
EC number
2.7.12.2
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Disease

CardiomyopathyDisease variantEctodermal dysplasiaIntellectual disability

Cellular component

CytoplasmMembrane

Molecular function

KinaseSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

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