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Claudin 1 Polyclonal Antibody

CAT: 0763-E-AB-12455-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-12455-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Abbreviation
CLDN1
UniProt
O95832
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide of human CLDN1
Target
Claudin-1; Claudin1; CLD 1; CLD1; CLD1; CLDN 1; Cldn1; ILVASC; SEMP 1; SEMP1; Senescence associated epithelial membrane protein 1; Senescence associated epithelial membrane protein; Senescence-associated epithelial membrane protein
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Signal Transduction
Purification
Affinity purification
Concentration
0.5 mg/mL
Dilution
WB 1:1000-1:3000; IHC 1:100-1:300
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
23kDa
Citation 01
https://www.sciencedirect.com/science/article/pii/S0378874122010066
Citation 02
https://onlinelibrary.wiley.com/doi/abs/10.1111/boc.201900085
Isotype
IgG

UniProtKB · O95832

Claudin-1

CLD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95832
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLDN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Cellular component

Cell junctionCell membraneMembraneTight junction

PTM

Disulfide bond

Molecular function

Host cell receptor for virus entryReceptor

Biological process

Host-virus interaction

Disease

Ichthyosis

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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