COMP Polyclonal Antibody

CAT: 0763-E-AB-11095-04Size: 200 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-11095-04Size:200 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) .

Abbreviation

COMP

UniProt

P49747

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant protein of human COMP

Target

Cartilage oligomeric matrix protein (pseudoachondroplasia; epiphyseal dysplasia 1; multiple) ; Cartilage oligomeric matrix protein; Cartilage oligomeric matrix protein precursor; COMP; COMP; EDM 1; EDM1; EPD 1; EPD1; Epiphyseal dysplasia 1; Epiphyseal dysplasia 1 multiple; Epiphyseal dysplasia multiple 1; MED; MGC13181; MGC149768; PSACH; pseudoachondroplasia (epiphyseal dysplasia 1; multiple) ; Pseudoachondroplasia; THBS 5; THBS5; Thrombospondin 5; Thrombospondin-5; Thrombospondin5; TSP5

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Cancer; Cell Biology; Signal Transduction; Stem Cells

Purification

Affinity purification

Concentration

0.3 mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:200

Buffer

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

83kDa

Citation 01

https://www.mdpi.com/2076-2615/10/12/2420

Isotype

IgG

UniProtKB · P49747

Cartilage oligomeric matrix protein

COMP_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P49747
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: COMP
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: COMP
EC number: —
Processing: Precursor
Secondary accessions: B4DKJ3, O14592, Q16388, Q16389, Q2NL86, Q8N4T2

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell adhesion

Ligand

Calcium

Disease

Disease variantDwarfism

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainRepeatSignal

Cellular component

Extracellular matrixSecreted

Molecular function

Heparin-binding

Related Products

Catalog	Name
E-KAB-0261	Human COMP Antibody Pair Set
PKSH031804	Recombinant Human COMP Protein (His Tag)
PDEH100417-01	Recombinant Human COMP protein (GST,His tag)
PDEH101069-01	Recombinant Human COMP protein (GST, His tag)
E-CL-R0116-01	Rat COMP -Cartilage Oligomeric Matrix Protein- CLIA Kit
E-EL-H0654-01	Human COMP (Cartilage Oligomeric Matrix Protein) ELISA Kit
E-CL-H0499-01	Human COMP (Cartilage Oligomeric Matrix Protein) CLIA Kit
E-EL-M0237-01	Mouse COMP-Cartilage Oligomeric Matrix Protein- ELISA Kit
E-EL-R0159-01	Rat COMP (Cartilage Oligomeric Matrix Protein) ELISA Kit
E-CL-M0172-01	Mouse COMP -Cartilage Oligomeric Matrix Protein- CLIA Kit

Alternative Products

Catalog	Name
MBS2565595-01	COMP Polyclonal Antibody
BS7875	COMP polyclonal antibody