USP2 Polyclonal Antibody

• Background :

  This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

• Abbreviation :

  USP2

• UniProt :

  O75604

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant protein of human USP2

• Target :

  41 kDa ubiquitin specific protease;41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin carboxyl terminal hydrolase 2; Ubiquitin carboxyl-terminal hydrolase 2; ubiquitin specific peptidase 2; Ubiquitin specific processing protease 2; Ubiquitin specific protease 12; Ubiquitin specific protease 9; Ubiquitin specific protease;41kD; Ubiquitin thioesterase 2; Ubiquitin thiolesterase 2; Ubiquitin-specific-processing protease 2; Ubiquitin-specific-processing protease testis; UBP-t; UBP2; UBP41; USP2; USP9

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC

• Field of Research :

  Cell Biology; Epigenetics and Nuclear Signaling

• Purification :

  Affinity purification

• Concentration :

  0.3 mg/mL

• Dilution :

  IHC 1:50-1:200

• Buffer :

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype :

  IgG