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TNFRSF11B Polyclonal Antibody

CAT: 0763-E-AB-10508-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10508-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Abbreviation
TNFRSF11B
UniProt
O00300
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant protein of human TNFRSF11B
Target
MGC29565; OCIF; OPG; Osteoclastogenesis inhibitory factor; Osteoprotegerin; PDB5; TNF receptor superfamily member 11b; TNFRSF 11B; TNFRSF11B; TR 1; TR1; TR11B; Tumor necrosis factor receptor superfamily member 11B
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cancer; Cardiovascular; Metabolism; Immunology; Signal Transduction
Purification
Affinity purification
Concentration
0.3 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:25-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
46kDa
Citation 01
https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.14218
Citation 02
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367655/
Isotype
IgG

UniProtKB · O00300

Tumor necrosis factor receptor superfamily member 11B

TR11B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00300
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF11B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R9A8, O60236, Q53FX6, Q9UHP4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Apoptosis

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Molecular function

Receptor

Domain

RepeatSignal

Cellular component

Secreted

Related Products

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AN001770P-01Osteoprotegerin/TNFRSF11B Monoclonal Antibody (Detector)
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PDEM100063-01Recombinant Mouse OPG/Tnfrsf11b protein (His tag)
PKSM041265-01Recombinant Mouse Osteoprotegerin/TNFRSF11B Protein (His Tag)
PKSH033573-01Recombinant Human Osteoprotegerin/TNFRSF11B Protein (His Tag)
PDEM100269-01Recombinant Mouse OPG/Tnfrsf11b protein (His tag)
PKSH031716-01Recombinant Human Osteoprotegerin/TNFRSF11B Protein (His Tag)
PKSM040324Recombinant Mouse Osteoprotegerin/TNFRSF11B Protein (Fc Tag)
PKSH033124-01Recombinant Human Osteoprotegerin/TNFRSF11B Protein (Fc Tag)

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MBS2519320-01TNFRSF11B Polyclonal Antibody
PTX18692-100TNFRSF11B Polyclonal Polyclonal Antibody
AF8202TNFRSF11B Rabbit Polyclonal Antibody
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