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Polygalacic acid

CAT: 0804-HY-N0801-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0801-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].
CAS Number
22338-71-2
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE) ; MMP
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/polygalacic-acid.html
Purity
98.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@]([C@@]1([H])[C@]2(C[C@H](O)[C@@H]3O)C)(CC[C@@]2([H])[C@]3(C)CO)[C@@](C4=CC1)(C[C@@H](O)[C@]5(C(O)=O)[C@@]4([H])CC(C)(C)CC5)C
Molecular Formula
C30H48O6
Molecular Weight
504.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct;63:246-252.|[2]Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15;23 (2) :149-55.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AChE

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