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Verbenalin

CAT: 0804-HY-N2014-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2014-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Verbenalin is an orally active terpenoid glycoside that can be extracted from the medicinal plant Verbena officinalis. Verbenalin has anti-inflammatory, antiviral, and neuroprotective effects. Verbenalin has a strong binding affinity to the nsp-12 protein of the SARS-CoV-2 virus. Verbenalin can be used in the research of inflammatory and nervous system diseases such as hepatitis and Alzheimer's disease[1][2][3][4][5].
CAS Number
548-37-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Amyloid-β; Bcl-2 Family; Caspase; Ferroptosis; SARS-CoV; Tau Protein
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/verbenalin.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CO[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@]3([H])[C@]1([H])C(C[C@@H]3C)=O)OC
Molecular Formula
C17H24O10
Molecular Weight
388.37
Precautions
H302, H315, H319
References & Citations
[1]Miao M, et al. Effects of verbenalin on prostatitis mouse model. Saudi J Biol Sci. 2016 Jan;23 (1) :S148-57.|[2]Cao L, et al. The protective role of verbenalin in rat model of focal cerebral ischemia reperfusion. Saudi J Biol Sci. 2018 Sep;25 (6) :1170-1177.|[3]Hafiza Salaha Mahrosh, et al. An in silico approach to target RNA-dependent RNA polymerase of COVID-19 with naturally occurring phytochemicals. Environ Dev Sustain. 2021 Apr 3;1-14.|[4]Lim J, et al. Verbenalin Reduces Amyloid-Beta Peptide Generation in Cellular and Animal Models of Alzheimer's Disease. Molecules. 2022 Dec 8;27 (24) :8678.|[5]Dong J, et al. Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX/PPARα-mediated ferroptosis. J Ethnopharmacol. 2023 May 10;307:116227.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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