APC Anti-Mouse CD150/SLAM Antibody[TC15-12F12.2]

• Background:

  CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.

• Abbreviation:

  CD150

• Gene ID:

  27218

• UniProt:

  Q9QUM4

• Host:

  Rat

• Reactivity:

  Mouse

• Target:

  CD 150; Signaling lymphocytic activation molecule; Slam; Slamf1

• Clonality:

  Monoclonal

• Clone:

  TC15-12F12.2

• Conjugation:

  APC

• Applications:

  FCM

• Concentration:

  0.2 mg/mL

• Buffer:

  Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

• Recommended Usage:

  6

• Isotype:

  Rat IgG2a, λ