Biotin Anti-Mouse CD274/PD-L1 Antibody[10F.9G2]

• Background:

  CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

• Abbreviation:

  CD274

• Gene ID:

  60533

• UniProt:

  Q9EP73

• Host:

  Rat

• Reactivity:

  Mouse

• Target:

  B7H1PD-L1PDCD1L1PDCD1LG1PDL1; B7 homolog 1; B7-H; B7-H1; Programmed cell death ligand 1

• Clonality:

  Monoclonal

• Clone:

  10F.9G2

• Conjugation:

  Biotin

• Applications:

  FCM

• Field of Research:

  Cancer Biomarkers; Costimulatory Molecules; Immunology

• Concentration:

  0.5 mg/mL

• Buffer:

  Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This product can be stored at 2-8°C for 12 months. Do not freeze.

• Recommended Usage:

  6

• Isotype:

  Rat IgG2b, κ