CASP8-IN-1

• UNSPSC Description:

  CASP8-IN-1 (Compound 63-R) is a selective inhibitor for caspase 8 (CASP8), with an IC50 of 0.7 μM. CASP8-IN-1 inhibits FasL-induced apoptosis in cell Jurkat[1].

• Target Antigen:

  Apoptosis; Caspase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/casp8-in-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  ClCC(N(C1=CC=CC=C1)[C@H]2CN(CCC2)C(C3=CC=C(N4CCOCC4)C=C3)=O)=O

• Molecular Weight:

  441.95

• References & Citations:

  [1]Backus KM, et al., Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  1956368-39-0