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CASP8-IN-1

CAT: 0804-HY-153161-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153161-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CASP8-IN-1 (Compound 63-R) is a selective inhibitor for caspase 8 (CASP8), with an IC50 of 0.7 μM. CASP8-IN-1 inhibits FasL-induced apoptosis in cell Jurkat[1].
CAS Number
1956368-39-0
UNSPSC
12352005
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/casp8-in-1.html
Purity
98.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClCC(N(C1=CC=CC=C1)[C@H]2CN(CCC2)C(C3=CC=C(N4CCOCC4)C=C3)=O)=O
Molecular Formula
C24H28ClN3O3
Molecular Weight
441.95
References & Citations
[1]Backus KM, et al., Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534 (7608) :570-4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 8

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