APC Anti-Mouse CD54 Antibody[YN1/1.7.4]

• Background:

  CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) . CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

• Abbreviation:

  CD54

• Gene ID:

  15894

• UniProt:

  P13597

• Host:

  Rat

• Reactivity:

  Mouse

• Target:

  CD54; Icam-1; Icam1; Intercellular adhesion molecule 1; MALA-2; MyD10

• Clonality:

  Monoclonal

• Clone:

  YN1/1.7.4

• Conjugation:

  APC

• Applications:

  FCM

• Field of Research:

  Cell Adhesion; Cell Biology; Costimulatory Molecules; Immunology; Innate Immunity; Neuroscience; Neuroscience Cell Markers; Stem Cells

• Concentration:

  0.2 mg/mL

• Buffer:

  Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

• Recommended Usage:

  6

• Isotype:

  Rat IgG2b, κ