Purified Mouse IgG2b, κ Isotype Control[MPC-11]

• Background:

  CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naïve T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines.

• Host:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  MPC-11

• Conjugation:

  Unconjugated

• Applications:

  FCM

• Concentration:

  ≥ 1 mg/mL

• Buffer:

  Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

• Recommended Usage:

  Each lot of this antibody is quality control tested by flow cytometric analysis as negative control. Use at concentrations comparable to those of the specific antibody of interest.

• Isotype:

  Mouse IgG2b, κ