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Cephalothin

CAT: 0804-HY-B1275A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1275A-01Size:100 mg
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Description
Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies[1][2][3][4][5][6][7].
CAS Number
153-61-7
Product Name Alternative
Cephalotin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cephalothin.html
Purity
99.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](NC(CC3=CC=CS3)=O)C1=O)O
Molecular Formula
C16H16N2O6S2
Molecular Weight
396.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Morandi S, et al. Structure-based optimization of cephalothin-analogue boronic acids as beta-lactamase inhibitors. Bioorg Med Chem. 2008 Feb 1;16 (3) :1195-205. Epub 2007 Nov 7.|[2]Desiderio JV, et al. Intraphagocytic killing of Salmonella typhimurium by liposome-encapsulated cephalothin. J Infect Dis. 1983 Sep;148 (3) :563-70.|[3]Mobashery S, et al. Reactions of Escherichia coli TEM beta-lactamase with cephalothin and with C10-dipeptidyl cephalosporin esters. J Biol Chem. 1986 Jun 15;261 (17) :7879-87.|[4]Cazenave J-P, et al. Effects of cephalothin and penicillin G on platelet function in vitro. Br J Haematol. 1977 Jan;35 (1) :135-52.|[5]Miraglia GJ, et al. Comparison of the chemotherapeutic and pharmacodynamic activities of cephradine, cephalothin, and cephaloridine in mice. Antimicrob Agents Chemother. 1973 Feb;3 (2) :270-3. |[6]Dellinger P, et al. Protective effect of cephalothin against gentamicin-induced nephrotoxicity in rats. Antimicrobial Agents and Chemotherapy, 1976, 9 (1) : 172-178.|[7]Goering RV, et al. Comparison of BL-S786 with cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice. J Antibiot (Tokyo) . 1978 Apr;31 (4) :363-72.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
β-lactam

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