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Seconeolitsine

CAT: 0804-HY-N10495-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N10495-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA) . Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics[1].
CAS Number
2650074-56-7
UNSPSC
12352005
Target
Antibiotic; Bacterial; Topoisomerase
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/seconeolitsine.html
Purity
98.65
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CNCCC1=C2C=CC3=CC(OCO4)=C4C=C3C2=C5OCOC5=C1
Molecular Formula
C19H17NO4
Molecular Weight
323.34
References & Citations
[1]María Teresa García, et al. New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumonia. J Biol Chem. 2011 Feb 25;286 (8) :6402-13.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo I

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