OXFBD04

• Description :

  OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity[1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/oxfbd04.html

• Concentration :

  10mM

• Purity :

  98.99

• Solubility :

  DMSO : ≥ 250 mg/mL

• Smiles :

  OC(C1=CC(O)=CC(C2=C(C)ON=C2C)=C1)C3=CC=CN=C3

• Molecular Formula :

  C17H16N2O3

• Molecular Weight :

  296.32

• References & Citations :

  [1]Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15;26 (11) :2937-2957.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  BRD4

• CAS Number :

  [2231747-03-6]