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QX77

CAT: 0804-HY-112483-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-112483-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells[1]. QX77 can impede self-renewal and promote differentiation of ES cells[2].
CAS Number
1798331-92-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/QX77.html
Purity
99.48
Solubility
DMSO : 15 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1)=O
Molecular Formula
C16H13ClN2O2
Molecular Weight
300.74
Precautions
H302, H315, H319, H335
References & Citations
[1]Jinzhong Zhang, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292 (25) :10328-10346|[2]Yi Xu, et al. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 Jul 24;369 (6502) :397-403.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-[4-(7-Chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide
CAS Number1798331-92-6
PubChem CID118129505
IUPAC NameN-[4-(7-chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide
Molecular FormulaC16H13ClN2O2
Molecular Weight300.74
XLogP2.9
Topological Polar Surface Area50.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity419
SMILES
CC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Cl)OC2
InChI
InChI=1S/C16H13ClN2O2/c1-10(20)18-13-5-2-11(3-6-13)15-9-21-16-8-12(17)4-7-14(16)19-15/h2-8H,9H2,1H3,(H,18,20)
InChIKey
PYCTUCLCTVWILY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[4-(7-Chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide
CAS: 1798331-92-6
CID: 118129505
Formula: C16H13ClN2O2
MW: 300.74
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight300.74
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass300.0665554
Monoisotopic Mass300.0665554
Topological Polar Surface Area50.7 Ų
Heavy Atom Count21
Formal Charge0
Complexity419
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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