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Lalistat 2

CAT: 0804-HY-128144-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128144-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells [1][2][3].
CAS Number
1234569-09-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Lipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lalistat-2.html
Purity
99.87
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3
Molecular Formula
C13H20N4O2S
Molecular Weight
296.40
Precautions
H302, H315, H319
References & Citations
[1]Bradić I, et al. Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases. Mol Metab. 2022, 61, 101519.|[2]Rosenbaum AI, et al. Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J Med Chem. 2010, 53 (14) :5281-9. |[3]Lukacs Z, et al. Best practice in the measurement and interpretation of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2. Clin Chim Acta. 2017;471:201-205.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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