Omtriptolide

• Description:

  Omtriptolide (PG490-88) is a derivative proagent of triptolide purified from the Chinese herb.

• Product Name Alternative:

  PG 490-88

• UNSPSC:

  12352005

• Target:

  Apoptosis; IFNAR; Interleukin Related; NF-κB; TGF-β Receptor; TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; NF-κB; TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Omtriptolide.html

• Purity:

  97.02

• Solubility:

  H2O : 1.39 mg/mL (ultrasonic)

• Smiles:

  C[C@@]([C@@]1([H])C[C@@H]2O3)(CCC4=C1COC4=O)[C@]5([C@H]([C@H]6[C@]7(C(C)C)O6)O5)[C@]23[C@@H]7OC(CCC(O)=O)=O

• Molecular Formula:

  C24H28O9

• Molecular Weight:

  460.47

• References & Citations:

  [1]Kim HJ, et al. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun;349 (3) :518-25.|[2]Leonard CT, et al. PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. J Heart Lung Transplant. 2002 Dec;21 (12) :1314-8.|[3]Krishna G, et al. PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis. Am J Pathol. 2001 Mar;158 (3) :997-1004.|[4]Chen BJ, et al. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000 Nov 27;70 (10) :1442-7.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ERK

• CAS Number:

  [195883-06-8]