Dolasetron

• Description:

  Dolasetron (MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

• Product Name Alternative:

  MDL-73147

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Dolasetron.html

• Concentration:

  10mM

• Purity:

  98.0

• Solubility:

  DMSO : ≥ 300 mg/mL

• Smiles:

  O=C(C1=CNC2=C1C=CC=C2)O[C@@H]3C[C@@](CC4C5)([H])[N@](CC4=O)[C@@]5([H])C3

• Molecular Formula:

  C19H20N2O3

• Molecular Weight:

  324.37

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7 (1) :50-8.|[2]Schwartzberg L, et al. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) . Support Care Cancer. 2014 Feb;22 (2) :469-77.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Lactoferrin

• CAS Number:

  [115956-12-2]