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Mouse MERTK / Mer Protein

CAT: 0013-GTR18990414-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18990414-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tyrosine-protein kinase Mer (MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs) -mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Product Name Alternative
MERTK, Mer
UniProt
Q60805
Expression Region
Gly 19 - Met 497
Reactivity
Mouse
Conjugation
Unconjugated
Tag
C-10xHis
Source
Mouse MERTK, His Tag (orb1496231) is expressed from human 293 cells (HEK293) . It contains AA Gly 19 - Met 497 (Accession # Q60805-1) .
Field of Research
Signal Transduction
Endotoxin
1.0 EU per μg
Purity
95%
Form
Liquid
Molecular Weight
54.2 kDa
Storage Conditions
-70°C
Notes
For research use only.
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54.2 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Accession Number
Q60805
Preservative
PBS, pH7.4

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