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Mouse Alpha-Synuclein Protein

CAT: 0013-GTR18990402-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18990402-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD) . Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Product Name Alternative
NACP, PARK1, PARK4, PD1
UniProt
O55042
Expression Region
Met 1 - Ala 140
Reactivity
Mouse
Conjugation
Unconjugated
Tag
C-10xHis
Source
Mouse Alpha-Synuclein, His Tag (orb1496218) is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # O55042-1) .
Field of Research
Neuroscience
Endotoxin
0.01 EU per μg
Purity
95%
Form
Liquid
Molecular Weight
16.4 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.4 kDa. The protein migrates as 19-21 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .
NCBI Accession Number
O55042
Preservative
100 mM NaAC, pH7.0

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