Uracil

CAT: 0804-HY-I0960-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-I0960-01Size:1 g
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Description
Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins[1][2][3][4][5].
CAS Number
[66-22-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Derivative; Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2,4_1H,3H_-Pyrimidinedione.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : ≥ 25 mg/mL
Smiles
O=C1NC(C=CN1)=O
Molecular Formula
C4H4N2O2
Molecular Weight
112.09
Precautions
H302, H315, H319, H335
References & Citations
[1]Pałasz A, et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem. 2015 Jun 5;97:582-611.|[2]Viswanathan A, et al. Phenotypic change caused by transcriptional bypass of uracil in nondividing cells. Science. 1999 Apr 2;284 (5411) :159-62.|[3]Visnes T, et al. Uracil in DNA and its processing by different DNA glycosylases. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364 (1517) :563-8.|[4]Ikenaka K, et al. Effect of uracil on metabolism of 5-fluorouracil in vitro. Gan. 1979 Jun;70 (3) :353-9. |[5]de Koning HP, et al. A highly selective, high-affinity transporter for uracil in Trypanosoma brucei brucei: evidence for proton-dependent transport. Biochem Cell Biol. 1998;76 (5) :853-8.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite

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