PF-06821497
CAT:
804-HY-101571A-01
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PF-06821497
- CAS Number: 1844849-10-0
- UNSPSC Description: PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value [1].
- Target Antigen: Epigenetic Reader Domain; Histone Methyltransferase
- Type: Reference compound
- Related Pathways: Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/pf-06821497.html
- Purity: 99.82
- Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C1N(CC2=C(OC)C=C(C)NC2=O)CCC3=C1C(Cl)=C([C@H](OC)C4COC4)C=C3Cl
- Molecular Weight: 467.34
- References & Citations: [1]Kung PP, et al. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J Med Chem. 2018 Feb 8;61(3):650-665.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: Phase 3