CZ415

CAT: 0804-HY-100222-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100222-01Size:1 mg
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Description
CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07. CZ415 inhibits mTORC1 and mTORC2 protein complex.
CAS Number
[1429639-50-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CZ415.html
Concentration
10mM
Purity
98.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CS(C3(C)C)(=O)=O)C(N4[C@@H](C)COCC4)=N2
Molecular Formula
C22H29N5O4S
Molecular Weight
459.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Cansfield AD, et al. CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model. ACS Med Chem Lett. 2016 Jun 10;7 (8) :768-73.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; mTORC1; mTORC2

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