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LY487379

CAT: 0804-HY-122255-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122255-01Size:5 mg
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Description
LY487379 is a selective human mGluR2 positive allosteric modulator (PAM) . LY487379 potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research[2].
CAS Number
353231-17-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly487379.html
Concentration
10mM
Purity
98.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)CS(=O)(N(C1=CC=C(OC2=CC=CC=C2OC)C=C1)CC3=CC=CN=C3)=O
Molecular Formula
C21H19F3N2O4S
Molecular Weight
452.45
Precautions
H302, H315, H319
References & Citations
[1]Nikiforuk A, et al. Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats. J Pharmacol Exp Ther. 2010;335 (3) :665-673.|[2]Schaffhauser H, et al. Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol Pharmacol. 2003;64 (4) :798-810.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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