Chymostatin

• Description:

  Chymostatin is a SARS-CoV-2 Mpro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer[1][2][3][4][5][6][7].

• UNSPSC:

  12352209

• Target:

  Interleukin Related; NF-κB; SARS-CoV; Virus Protease

• Type:

  Peptides

• Related Pathways:

  Anti-infection; Immunology/Inflammation; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/chymostatin.html

• Purity:

  99.9

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Molecular Weight:

  607.70

• References & Citations:

  [1]Chen Yang, et al. Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice. Inflammation|[2]Lane JT, et al. Chymostatin inhibits cellular aggregation of activated human peripheral blood lymphocytes. Life Sci. 1980 Aug 11;27 (6) :451-6.|[3]Qiu M, et al. Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells. Lipids Health Dis. 2018 Jul 31;17 (1) :183.|[4]Abstract LB074: Chymostatin, a cathepsin L inhibitor, inhibits lung cancer cell proliferation and COVID-19 Mpro in vitro.|[5]Libby P, et al. Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle. Biochem J. 1980 Apr 15;188 (1) :213-20.|[6]Roszkowska-Chojecka MM, et al. Effects of chymostatin, a chymase inhibitor, on blood pressure, plasma and tissue angiotensin II, renal haemodynamics and renal excretion in two models of hypertension in the rat. Exp Physiol. 2015 Sep;100 (9) :1093-105.|[7]Komatsu K, et al. Beneficial effect of chymostatin on dystrophic mice. Exp Neurol. 1986 Jul;93 (1) :110-6.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  IL-1; IL-6; NF-κB

• CAS Number:

  [9076-44-2]