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Reldesemtiv

CAT: 0804-HY-109121-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109121-01Size:1 mg
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Description
Reldesemtiv (CK-2127107) is a selective, orally active and next-generation fast skeletal muscle troponin activator (FSTA) . Reldesemtiv selectively activates fast skeletal myofibrils with an EC50 of 3.4 μM. Reldesemtiv increases exercise performance in a heart failure model[1].
CAS Number
1345410-31-2
Product Name Alternative
CK-2127107
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/reldesemtiv.html
Concentration
10mM
Purity
99.63
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(C2=CN=C(NC[C@]3(C4=NC=CC=C4F)C[C@H](F)C3)N=C2)C=C1)N
Molecular Formula
C19H18F2N6O
Molecular Weight
384.38
References & Citations
[1]Hwee DT, et al. The small-molecule fast skeletal troponin activator, CK-2127107, improves exercise tolerance in a rat model of heart failure. J Pharmacol Exp Ther. 2015 Apr;353 (1) :159-68.|[2]Andrews JA, et al. CK-2127107 amplifies skeletal muscle response to nerve activation in humans. Muscle Nerve. 2018 May;57 (5) :729-734.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
VDC41031-01Reldesemtiv
AR-R10505-01Reldesemtiv-d4

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