Clonidine (hydrochloride)
CAT:
804-HY-B0409A-02
Size:
5 g
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Clonidine (hydrochloride)
- CAS Number: 4205-91-8
- UNSPSC Description: Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
- Target Antigen: Adrenergic Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Neuronal Signaling
- Applications: COVID-19-immunoregulation
- Field of Research: Cardiovascular Disease; Endocrinology; Cancer
- Assay Protocol: https://www.medchemexpress.com/Clonidine-hydrochloride.html
- Purity: 99.96
- Solubility: DMSO : 7.6 mg/mL (ultrasonic;warming)|H2O : 33.33 mg/mL (ultrasonic)
- Smiles: ClC1=C(NC2=NCCN2)C(Cl)=CC=C1.Cl
- Molecular Weight: 266.55
- References & Citations: [1]Bugajski J, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15.|[2]Zhang YM, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52.|[3]Jentsch JD, et al. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6.|[4]Nassar N, et al. Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. J Pharmacol Exp Ther. 2009 Jan;328(1):83-9.Cell Rep. 2019 Dec 3;29(10):2929-2935.e4|Elife. 2024 May 29.|Neurosci Bull. 2022 Apr;38(4):386-402.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|medRxiv. 2024 May 31.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched