Bradykinin
CAT:
804-HY-P0206-05
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Bradykinin
- CAS Number: 58-82-2
- UNSPSC Description: Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain[1][2][3][4][5].
- Target Antigen: Bradykinin Receptor; Endogenous Metabolite; Ser/Thr Protease
- Type: Peptides
- Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease
- Applications: COVID-19-immunoregulation
- Field of Research: Cardiovascular Disease; Endocrinology
- Assay Protocol: https://www.medchemexpress.com/Bradykinin.html
- Purity: 99.92
- Solubility: 10 mM in DMSO|H2O : ≥ 100 mg/mL
- Smiles: O=C(N1[C@@H](CCC1)C(NCC(N[C@H](C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CC=CC=C4)=O)=O)[C@H]5N(CCC5)C([C@@H](N)CCCNC(N)=N)=O
- Molecular Weight: 1060.21
- References & Citations: [1]Hornig B, et al. Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors inhumans. Circulation. 1997 Mar 4;95(5):1115-8.|[2]Wang G, et al. Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. Oncol Rep. 2014 Oct;32(4):1709-14.|[3]Dong R, et al. Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway. Cell Physiol Biochem. 2015;37(4):1592-606.|[4]Uchida S, et al. Afferent fibers involved in the bradykinin-induced cardiovascular reflexes from the ovary in rats. Auton Neurosci. 2015 Dec;193:57-62.|[5]Liu LT, et al. Effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. Eur Rev Med Pharmacol Sci. 2015;19(14):2646-50.
- Shipping Conditions: Blue Ice
- Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
- Clinical Information: Phase 4